Lateral ventricle injection of the protein synthesis inhibitor anisomycin impairs long-term memory in a spatial memory task.

UI - 98270015

PMID- 9602054

DA - 19980727

DCOM- 19980727

LR - 20001218

IS - 0006-8993

VI - 789

IP - 1

DP - 1998 Apr 6

TI - Lateral ventricle injection of the protein synthesis inhibitor anisomycin impairs long-term memory in a spatial memory task.

PG - 48-55 AB - Although protein synthesis inhibition has been shown to affect long-term memory in a wide variety of animal species, cases have been reported in which protein synthesis inhibition failed to affect memory consolidation [S. Wittstock, R. Menzel, Color learning and memory in honey bees are not affected by protein synthesis inhibition, Behav. Neural Biol., 62 (1994) 224-229.]. Most findings argue that the critical time for protein synthesis is during or immediately after training. However, other reports show a second time window, hours after training, where protein synthesis inhibition can cause amnesia [F.M. Freeman, S.P.R. Rose, A.B. Scholey, Two time windows of anisomycin-induced amnesia for passive avoidance training in the day-old chick, Neurobiol. Learn. Mem., 63 (1995) 291-295.][G. Grecksch, H. Matthies, Two sensitive periods for the amnesic effect of anisomycin, Pharmacol. Biochem. Behav., 12 (1980) 663-665.]. In this study, we addressed two questions: (1) Is protein synthesis essential for spatial memory? and (2) At what injection time window(s) will protein synthesis inhibition cause spatial memory amnesia? We report that bilateral intraventricular microinjection of anisomycin (Ani) impairs consolidation of long-term memory, in the hippocampal-dependent Morris water maze spatial memory task. Memory was impaired in a dose-dependent manner without affecting short-term memory. Spatial memory was affected only if Ani was injected 20 min before performing the task and not in any other time window before or after the behavioral test. The inhibition did not affect pre-existing memories or the capability to memorize once the effect of the inhibition diminished.

AD - Laboratory of Adaptive Systems, National Institutes of Health, Bethesda,


FAU - Meiri, N

AU - Meiri N

FAU - Rosenblum, K

AU - Rosenblum K

LA - eng

PT - Journal Article


TA - Brain Res

JID - 0045503

RN - 0 (Protein Synthesis Inhibitors)

RN - 22862-76-6 (Anisomycin)


MH - Animal

MH - Anisomycin/*pharmacology

MH - Dose-Response Relationship, Drug

MH - Injections, Intraventricular

MH - Male

MH - Maze Learning/physiology

MH - Memory/*drug effects

MH - Protein Synthesis Inhibitors/*pharmacology

MH - Rats

MH - Rats, Wistar

MH - Space Perception/*physiology

MH - Time Factors

EDAT- 1998/05/29

MHDA- 1998/05/29 00:01

AID - S000689939701528X [pii]



PST - ppublish

SO - Brain Res 1998 Apr 6;789(1):48-55.

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