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PMID- 9602054
DA - 19980727
DCOM- 19980727
LR - 20001218
IS - 0006-8993
VI - 789
IP - 1
DP - 1998 Apr 6
TI - Lateral ventricle injection of the protein synthesis inhibitor anisomycin impairs long-term memory in a spatial memory task.
PG - 48-55 AB - Although protein synthesis inhibition has been shown to affect long-term memory in a wide variety of animal species, cases have been reported in which protein synthesis inhibition failed to affect memory consolidation [S. Wittstock, R. Menzel, Color learning and memory in honey bees are not affected by protein synthesis inhibition, Behav. Neural Biol., 62 (1994) 224-229.]. Most findings argue that the critical time for protein synthesis is during or immediately after training. However, other reports show a second time window, hours after training, where protein synthesis inhibition can cause amnesia [F.M. Freeman, S.P.R. Rose, A.B. Scholey, Two time windows of anisomycin-induced amnesia for passive avoidance training in the day-old chick, Neurobiol. Learn. Mem., 63 (1995) 291-295.][G. Grecksch, H. Matthies, Two sensitive periods for the amnesic effect of anisomycin, Pharmacol. Biochem. Behav., 12 (1980) 663-665.]. In this study, we addressed two questions: (1) Is protein synthesis essential for spatial memory? and (2) At what injection time window(s) will protein synthesis inhibition cause spatial memory amnesia? We report that bilateral intraventricular microinjection of anisomycin (Ani) impairs consolidation of long-term memory, in the hippocampal-dependent Morris water maze spatial memory task. Memory was impaired in a dose-dependent manner without affecting short-term memory. Spatial memory was affected only if Ani was injected 20 min before performing the task and not in any other time window before or after the behavioral test. The inhibition did not affect pre-existing memories or the capability to memorize once the effect of the inhibition diminished.
AD - Laboratory of Adaptive Systems, National Institutes of Health, Bethesda,
[emd]
FAU - Meiri, N
AU - Meiri N
FAU - Rosenblum, K
AU - Rosenblum K
LA - eng
PT - Journal Article
CY - NETHERLANDS
TA - Brain Res
JID - 0045503
RN - 0 (Protein Synthesis Inhibitors)
RN - 22862-76-6 (Anisomycin)
SB - IM
MH - Animal
MH - Anisomycin/*pharmacology
MH - Dose-Response Relationship, Drug
MH - Injections, Intraventricular
MH - Male
MH - Maze Learning/physiology
MH - Memory/*drug effects
MH - Protein Synthesis Inhibitors/*pharmacology
MH - Rats
MH - Rats, Wistar
MH - Space Perception/*physiology
MH - Time Factors
EDAT- 1998/05/29
MHDA- 1998/05/29 00:01
AID - S000689939701528X [pii]
URLS- http://www.elsevier.com:80/cgi-bin/cas/tree/store/bres/cas_sub/browse/brow
se.cgi?year=1998&volume=789&issue=1&aid=14351
PST - ppublish
SO - Brain Res 1998 Apr 6;789(1):48-55.
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